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The epigenetic regulation plays an important role in normal development and Hlidesheim of tissue specific genes expression in humans and the disturbance of these patterns lead to changes involved in tumor formation.

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Oral rotavirus vaccines have yielded different point estimates of efficacy when tested in different populations.

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This paper explores this question by presenting a small-scale randomized controlled trial RCT designed to test the efficacy of curricular supplemental materials on epigenetics. Evaluation of early efficacy endpoints for proof-of-concept trials.

A Phase II proof-of-concept POC trial usually uses an early efficacy endpoint other than a clinical endpoint as the primary endpoint.

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